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短链脱氢酶

维基百科,自由的百科全书
short chain dehydrogenase
鑑定
標誌adh_short
PfamPF00106旧版
InterPro英语InterProIPR002198
PROSITE英语PROSITEPDOC00060
SCOP英语Structural Classification of Proteins1hdc / SUPFAM
OPM英语Orientations of Proteins in Membranes database家族119
OPM英语Orientations of Proteins in Membranes database蛋白1xu7
CDD英语Conserved Domain Databasecd02266
膜蛋白數據庫英语Membranome246

短链脱氢酶(英語:Short-chain dehydrogenase,或称为短链脱氢/还原酶家族,英語:short-chain dehydrogenases/reductases family,缩写SDR[2]是一个非常大的蛋白质家族,属于 NAD- 或 NADP-依赖的氧化還原酶,第一个被鉴定的家族成员是黑腹果蝇醇脱氢酶,因此命名为“昆虫型”('insect-type')或“短链”('short-chain')醇脱氢酶[3][4][5]。大部分酶家族成员有250到300个氨基酸残基,且包含至少两个结构域[6]其中一个用于结合辅酶,大部分是NAD,少部分是NADP,另一个用于结合底物及催化。

人类基因组中的成员

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BDH1; BDH2; CBR1; CBR3; CBR4; DCXR; DECR1; DECR2; DHRS1; DHRS10; DHRS13; DHRS2; DHRS3; DHRS4; DHRS4L2; DHRS7; DHRS7B; DHRS8; DHRS9; DHRSX; FASN; FVT1; HADH2; HPGD; HSD11B1; HSD11B2; HSD17B1; HSD17B10; HSD17B12; HSD17B13; HSD17B2; HSD17B3; HSD17B4; HSD17B6; HSD17B7; HSD17B7P2; HSD17B8; HSDL1; HSDL2; PECR; QDPR; RDH10; RDH11; RDH12; RDH13; RDH14; RDH16; RDH5; RDH8; RDHE2; RDHS; SCDR10; SPR; WWOX;

参考文献

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  1. ^ Ghosh D, Erman M, Wawrzak Z, Duax WL, Pangborn W. Mechanism of inhibition of 3 alpha, 20 beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor. Structure. October 1994, 2 (10): 973–80. PMID 7866748. doi:10.1016/S0969-2126(94)00099-9. 
  2. ^ Persson B, Krook M, Atrian S, Gonzalez-Duarte R, Jeffery J, Ghosh D, Jornvall H. Short-chain dehydrogenases/reductases (SDR). Biochemistry. 1995, 34 (18): 6003–6013. PMID 7742302. doi:10.1021/bi00039a038. 
  3. ^ Villarroya A, Juan E, Egestad B, Jornvall H. The primary structure of alcohol dehydrogenase from Drosophila lebanonensis. Extensive variation within insect 'short-chain' alcohol dehydrogenase lacking zinc. Eur. J. Biochem. 1989, 180 (1): 191–197. PMID 2707261. doi:10.1111/j.1432-1033.1989.tb14632.x. 
  4. ^ Persson B, Krook M, Jornvall H. Characteristics of short-chain alcohol dehydrogenases and related enzymes. Eur. J. Biochem. 1991, 200 (2): 537–543. PMID 1889416. doi:10.1111/j.1432-1033.1991.tb16215.x. 
  5. ^ Harayama S, Bairoch A, Hartnett C, Rekik M, Ornston LN, Neidle E. cis-diol dehydrogenases encoded by the TOL pWW0 plasmid xylL gene and the Acinetobacter calcoaceticus chromosomal benD gene are members of the short-chain alcohol dehydrogenase superfamily. Eur. J. Biochem. 1992, 204 (1): 113–120. PMID 1740120. doi:10.1111/j.1432-1033.1992.tb16612.x. 
  6. ^ Benyajati C, Place AR, Powers DA, Sofer W. Alcohol dehydrogenase gene of Drosophila melanogaster: relationship of intervening sequences to functional domains in the protein. Proc. Natl. Acad. Sci. U.S.A. 1981, 78 (5): 2717–2721. PMC 319428可免费查阅. PMID 6789320. doi:10.1073/pnas.78.5.2717.