CCL9
外观
趋化因子(C-C基序)配体9 Chemokine (C-C motif) ligand 9 | |||||||||||||
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标识 | |||||||||||||
代号 | Ccl9; CCF18; MRP-2; Scya10; Scya9 | ||||||||||||
扩展标识 | 鼠基因:104533 同源基因:86734 GeneCards: Ccl9 Gene | ||||||||||||
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直系同源体 | |||||||||||||
物种 | 人类 | 小鼠 | |||||||||||
Entrez | 20308 | 20308 | |||||||||||
Ensembl | ENSMUSG00000019122 | ENSMUSG00000019122 | |||||||||||
UniProt | P51670 | P51670 | |||||||||||
mRNA序列 | NM_011338 | NM_011338 | |||||||||||
蛋白序列 | NP_035468 | NP_035468 | |||||||||||
基因位置 |
Chr 11: 83.57 – 83.58 Mb |
Chr 11: 83.57 – 83.58 Mb | |||||||||||
PubMed查询 | [1] | [2] | |||||||||||
CCL9(英語:Chemokine (C-C motif) ligand 9)是一个小型的细胞因子,属于CC趋化因子家族。它的别名有巨噬细胞炎性蛋白-1γ(英語:macrophage inflammatory protein-1 gamma,MIP-1γ), 巨噬细胞炎症蛋白相关蛋白-2(英語:macrophage inflammatory protein-related protein-2,MRP-2)以及在啮齿类中使用的CCF18。CCL9还曾经被定名为CCL10,但这个名称已不再使用。
它由淋巴结相关上皮组织(FAE)分泌(如Peyer氏斑块周围),并影响拥有细胞表面分子CD11b与趋化因子受体CCR1的树突状细胞[1]。 CCL9 通过其受体CCR1(破骨细胞中最丰富的趋化因子受体)激活破骨细胞,表明了CCL9可能在骨质吸收中的重要作用[2]。CCL9巨噬细胞和骨髓细胞里也持续表达[3][4]。编码CCL9的基因位于小鼠的11号染色体上[4]。
参考文献
[编辑]- ^ Zhao X, Sato A, Dela Cruz C, Linehan M, Luegering A, Kucharzik T, Shirakawa A, Marquez G, Farber J, Williams I, Iwasaki A. CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells. J Immunol. 2003, 171 (6): 2797–803. PMID 12960300.
- ^ Lean J, Murphy C, Fuller K, Chambers T. CCL9/MIP-1gamma and its receptor CCR1 are the major chemokine ligand/receptor species expressed by osteoclasts. J Cell Biochem. 2002, 87 (4): 386–93. PMID 12397598. doi:10.1002/jcb.10319.
- ^ Youn B, Jang I, Broxmeyer H, Cooper S, Jenkins N, Gilbert D, Copeland N, Elick T, Fraser M, Kwon B. A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors. J Immunol. 1995, 155 (5): 2661–7. PMID 7650394.
- ^ 4.0 4.1 Hara T, Bacon K, Cho L, Yoshimura A, Morikawa Y, Copeland N, Gilbert D, Jenkins N, Schall T, Miyajima A. Molecular cloning and functional characterization of a novel member of the C-C chemokine family. J Immunol. 1995, 155 (11): 5352–8. PMID 7594550.
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