CYP46A1
外观
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细胞色素 P450 46A1(英語:Cytochrome P450 46A1,缩写CYP46A1)也被称为胆固醇24-羟化酶(chilsterol 24-hydroxylase,EC 1.14.13.98),是细胞色素P450超家族的一员,由CYP46A1基因编码,是催化胆固醇生成羟基化生成脑甾醇(24S-羟基胆固醇)的酶[5]。
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Structure of cholesterol-24 hydroxlase (CYP46A1) in Homo sapiens. Based on PyMOL rendering of PDB 2Q9F. | |||||||
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识别码 | |||||||
EC編號 | 1.14.13.98 | ||||||
数据库 | |||||||
IntEnz | IntEnz浏览 | ||||||
BRENDA | BRENDA入口 | ||||||
ExPASy | NiceZyme浏览 | ||||||
KEGG | KEGG入口 | ||||||
MetaCyc | 代谢路径 | ||||||
PRIAM | 概述 | ||||||
PDB | RCSB PDB PDBj PDBe PDBsum | ||||||
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参考文献
[编辑]- ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000036530 - Ensembl, May 2017
- ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000021259 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Russell DW; Halford RW; Ramirez DMO; Shah R; Kotti T. Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain. Annual Review of Biochemistry. 2009, 78: 1017–1040. PMC 2837268
. PMID 19489738. doi:10.1146/annurev.biochem.78.072407.103859.
外部链接
[编辑]- GeneReviews/NCBI/NIH/UW entry on Cerebrotendinous Xanthomatosis(页面存档备份,存于互联网档案馆)
- 醫學主題詞表(MeSH):Cytochrome+P-450+CYP27A1
- Human CYP27A1 genome location and CYP27A1 gene details page in the UCSC Genome Browser.
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