GM2 (神经节苷脂)
外观
GM2 | |
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IUPAC名 (2S,3R,4E)-3-Hydroxy-2-octadecanamidooctadec-4-en-1-yl (5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosylonic acid)-(2→3)-[2-acetamido-2-deoxy-β-D-galactopyranosyl-(1→4)]-β-D-galactopyranosyl-(1→4)-β-D-glucopyranoside | |
系统名 (2S,4S,5R,6R)-5-Acetamido-2[(2R,3S,4R,5R,6S)-3[(2S,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy6[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-{[(2S,3R,4E)-3-hydroxy-2-octadecanamidooctadec-4-en-1-yl]oxy}oxan-3-yl]oxy5-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate | |
别名 | Ganglioside GM2; Tay–Sachs ganglioside; β-D-GalNAc-(1→4)-[α-Neu5Ac-(2→3)]-β-D-Gal-(1→4)-β-D-Glc-(1↔1)-N-octadecanoylsphingosine |
识别 | |
CAS号 | 19600-01-2 ![]() |
PubChem | 71308211 |
ChemSpider | 26286730 |
SMILES |
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InChI |
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InChIKey | USMMPBVNWHAJBE-YMEOXFOQBT |
ChEBI | 60327 |
性质 | |
化学式 | C67H121N3O26 |
摩尔质量 | 1384.68 g·mol−1 |
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。 |
在有机化学中,GM2是神经节苷脂的一种。G指神经节苷脂,M代表单唾液酸(因为它有一个唾液酸),2指它是第二种被发现的单唾液酸神经节苷脂。它与GM2神经节苷脂沉积症(例如泰-萨克斯病)有关。[1]
参见
[编辑]附加图集
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鞘脂沉积症
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GM1、GM2、GM3神经节苷脂的结构
参考资料
[编辑]- ^ Guetta E, Peleg L. Rapid Detection of Fetal Mendalian Disorders: Tay–Sachs Disease. Methods in Molecular Biology 444. 2008: 147–59. ISBN 978-1-58829-803-4. PMID 18425478. doi:10.1007/978-1-59745-066-9_11.
外部链接
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