TRIM21
外观
三分模體包含蛋白質21(Tripartite motif-containing protein 21,縮寫爲TRIM21),亦作E3泛素化蛋白質連接酶TRIM21(E3 ubiquitin-protein ligase TRIM21),係一種由人類TRIM21基因編碼的蛋白質[2][3]。人們已經發現了該蛋白質的可變剪切變體,但目前僅查明了其中一種在完整狀態下的性質。大部分人類組織都表達此種蛋白[4]。
結構
[编辑]TRIM21係TRIM蛋白質家族的成員。TRIM模體包含了三個鋅結合結構域、一個環指結構域、一個1型B箱、一個2型B箱鋅指,以及一個捲曲螺旋區域[3]。
功能
[编辑]TRIM21爲一種細胞內抗體介導蛋白水解途徑的細胞內抗體效應子。它會與標記感染細胞的無包膜病毒體的抗體上的免疫球蛋白G和免疫球蛋白M相連。隨後,其自身發生泛素化或一個輔助因子發生泛素化。其後,TRIM21會負責引導病毒體到有蛋白酶的位置。抗體和病毒的衣殼會被蛋白酶水解,但TRIM21卻不會[4]。
TRIM21爲RoSSA核糖核蛋白的一個組成成分。RoSSA還含有一條單多肽鏈以及一條小分子RNA(這條RNA有4種)。細胞質和細胞核中均有RoSSA粒子[3]。
臨床意義
[编辑]RoSSA會與乾燥綜合徵和全身性紅斑狼瘡患者體內的自身抗原反應[3]。亦有研究者以TRIM21爲基礎研發新藥[5]。
參考
[编辑]- ^ PDB 2IWG; James LC, Keeble AH, Khan Z, Rhodes DA, Trowsdale J. Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function. Proc. Natl. Acad. Sci. U.S.A. April 2007, 104 (15): 6200–5. PMC 1851072
. PMID 17400754. doi:10.1073/pnas.0609174104.
- ^ Frank MB, Itoh K, Fujisaku A, Pontarotti P, Mattei MG, Neas BR. The mapping of the human 52-kD Ro/SSA autoantigen gene to human chromosome 11, and its polymorphisms. Am J Hum Genet. Mar 1993, 52 (1): 183–91. PMC 1682114
. PMID 8094596.
- ^ 3.0 3.1 3.2 3.3 Entrez Gene: TRIM21 tripartite motif-containing 21.
- ^ 4.0 4.1 Mallery DL, McEwan WA, Bidgood SR, Towers GJ, Johnson CM, James LC. Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21). Proc. Natl. Acad. Sci. U.S.A. 2010, 107 (46): 19985–19990 [2016-02-08]. PMC 2993423
. PMID 21045130. doi:10.1073/pnas.1014074107. (原始内容存档于2019-09-06).
- ^ 黄堃. PNAS:揭开免疫系统消灭病毒机制 有助抗病毒药物研发. 新華網. [2016-02-09]. (原始内容存档于2016-07-03).
拓展閱讀
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