国际癌症研究机构二B类致癌物
外观
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2B类致癌物(英语:Group 2B carcinogens),为国际癌症研究机构对致癌物质的分类,此类物质(或其混合物)可能对人类致癌。截至2024年5月2日,共用323种[1]2B类致癌物(如黄樟素、四氯化碳、电磁波、抗甲状腺药物丙硫氧嘧啶、二异氰酸甲苯、抗艾滋病药物齐多夫定、汽油引擎废气、干洗业等),对人类为有可能致癌物,对动物为很可能也是致癌物。[2]更多详细信息,可以搜寻国际癌症研究机构(IARC)专著。[3]
物质和物质组合
[编辑]中文名称 | 学名 | CAS号 | 欧盟委员会编号 EINECS |
备考 |
---|---|---|---|---|
A-a-C (2-Amino-9H-pyrido[2,3-b]indole) | US Biological 化学试药类 | |||
乙醛 | Acetaldehyde | 0 | ||
乙酰胺 | Acetamide | 0 | ||
Acétate de médroxyprogestérone | 0 | |||
Acétate de méthylazoxyméthanol | 0 | |||
乙酸乙烯酯 | Acétate de vinyle | 0 | ||
咖啡酸 | Acide caféique | 0 | ||
Acide chlorendique | 0 | |||
二氯乙酸 | 0 | |||
氨三乙酸 | 0 | |||
Acrylate d'éthyle | 0 | |||
丙烯腈 | Acrylonitrile | 0 | ||
阿达帕林 | Adapalene | |||
AF-2 | Furylfuramide 2-(2-Furyl)-3-(5-nitro-2-furyl)acrylamide |
硝基蚨喃类杀菌剂,结构类似对羟基苯甲酸酯 | ||
黄曲毒素 M1 | Aflatoxin,M1 | 2 | ||
对-氨基偶氮苯 | Aniline Yellow para-Aminoazobenzene |
0 | 苯胺黄 | |
邻-氨基偶氮甲苯 | ortho-Aminoazotoluene | 0 | 苏丹红IV代谢生成的物质 | |
2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole | 1 | |||
胺苯吖啶 | Amsacrine | 5 | 抗肿瘤药,别名安丫啶、安吖啶 | |
邻氨基苯甲醚 | ortho-Anisidine | 0 | ||
三氧化二锑 | Antimony trioxide | 1 | ||
异黄樟 | Aramite | 别名杀螨特;异黄樟;杀螨剂 | ||
金胺O | Auramine | 0 | 工业级(technical-grade) | |
重氮乙酰丝氨酸 | Azaserine | 0 | 别名氮丝氨酸;氮杂丝氨酸;重氮丝氨酸 - 用以抑制某些肿瘤生长的抗生素 | |
氮丙环 | Aziridine | 0 | ||
Benz[j]aceanthrylene | (多环芳香烃,PAHs) | |||
Benz(''a'')anthracene | 0 | (多环芳香烃,PAHs) | ||
Benzo(b)fluoranthene | 0 | (多环芳香烃,PAHs) | ||
Benzo(j)fluoranthene | 0 | (多环芳香烃,PAHs) | ||
Benzo(k)fluoranthene | 0 | (多环芳香烃,PAHs) | ||
Benzo(''c'')phenanthrene | 0 | (多环芳香烃,PAHs) | ||
苯并呋喃 | Benzofurane、Benzofuran | 0 | (多环芳香烃,PAHs) | |
Benzyl violet 4B 酸性紫4B |
紫色1号,C39H40N3NaO6S2,3-[[Ethyl[4-[[4-(dimethyliminio)-2,5-cyclohexadiene-1-ylidene][4-[ethyl[3-(sodiooxysulfonyl)benzyl]amino]phenyl]methyl]phenyl]amino]methyl]benzenesulfonate | 1 | 主要用于羊毛、丝绸、锦纶的染色[4] | |
二溴新戊醇 2,2-双(溴甲基)-1,3-丙二醇 |
2,2-Bis(bromomethyl)propane-1,3-diol | 2 | 中间体或阻燃剂[5][6] | |
博来霉素 | Bleomycin | |||
Bracken fern | 蕨类植物;[7][8][9] | |||
溴二氯甲烷 | Bromodichloromethane | 0 | ||
丁基羟基茴香醚 | Butylated hydroxyanisole | 4 | ||
β-丁内酯 | b-Butyrolactone,别名4-甲基-β-丙酰内酯;B-丁内酯;Β-丁内酮,分子式为C4H6O2 | 2 | 酯类,可作单体[10][11] | |
碳烟 | Carbon black | |||
四氯化碳 | Carbon tetrachloride | |||
邻苯二酚 | Catechol | |||
氯丹 | Chlordane | |||
十氯酮 | (开蓬,杀虫﹑杀真菌药,原商标名) | |||
氯菌酸 | 六氯内-甲烯基-四氢苯二甲酸 | 毒性“气喘、肺水肿、过敏性皮肤炎、灼热疼痛感,视线模糊并流泪” | ||
4-氯苯胺 | para-Chloroaniline | 0 | ||
3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone | ||||
氯仿 | ||||
1-Chloro-2-methylpropene | ||||
Chlorophenoxy herbicides | ||||
4-Chloro-ortho-phenylenediamine | ||||
氯丁二烯 | ||||
百菌清 | ||||
䓛 | ||||
CI Acid Red 114 | ||||
副玫瑰苯胺 | ||||
CI Direct Blue 15 | ||||
Citrus Red 2 | ||||
钴以及钴化合物 | ||||
Cobalt sulfate and other soluble cobalt(II) salts | ||||
Cocamide DEA condensate | ||||
para-Cresidine | ||||
Cycasin | ||||
达卡巴嗪 | ||||
丹蒽醌 (Chrysazin, 1,8-Dihydroxyanthraquinone) | ||||
道诺霉素 | ||||
滴滴涕 (p,p'-DDT) | ||||
N,N'-Diacetylbenzidine | ||||
2,4-Diaminoanisole | ||||
4,4'-二氨基二苯醚 | ||||
2,4-Diaminotoluene | ||||
Dibenz[a,h]acridine | ||||
Dibenz[a,j]acridine | ||||
7H-Dibenzo[c,g]carbazole | ||||
Dibenzo[a,e]pyrene | ||||
Dibenzo[a,h]pyrene | ||||
Dibenzo[a,i]pyrene | ||||
1,2-二溴-3-氯丙烷 | ||||
2,3-Dibromopropan-1-ol | ||||
二氯乙酸 | ||||
对二氯苯 | ||||
3,3'-Dichlorobenzidine | ||||
3,3'-Dichloro-4,4'-diaminodiphenyl ether | ||||
1,2-二氯乙烷 | ||||
二氯甲烷 (methylene chloride) | ||||
1,3-Dichloropropene (technical grade) | ||||
敌敌畏 | ||||
1,2-Diethylhydrazine | ||||
Diglycidyl resorcinol ether | ||||
Dihydrosafrole |
- Diisopropyl sulfate
- 3,3'-Dimethoxybenzidine (o-Dianisidine)
- 甲基黄
- trans-2-[(Dimethylamino)methylimino]-5-[2-(5-nitro-2-furyl)-vinyl]-1,3,4-oxadiazole
- 2,6-Xylidine (2,6-Dimethylaniline)
- 3,3'-Dimethylbenzidine (o-Tolidine)
- 偏二甲肼
- 3,7-Dinitrofluoranthene
- 3,9-Dinitrofluoranthene
- 1,6-Dinitropyrene
- 1,8-Dinitropyrene
- 2,4-二硝基甲苯
- 二硝基甲苯
- 1,4-二𫫇烷
- Disperse Blue 1
- 1,2-环氧丁烷
- 丙烯酸乙酯
- 乙苯
- 1,2-二氯乙烷
- 甲磺酸乙酯
- Foreign bodies, implanted in tissues
- Polymeric, prepared as thin smooth films (with the exception of poly(glycolic acid))
- Metallic, prepared as thin smooth films
- Metallic cobalt, metallic nickel and an alloy powder containing 66-67% nickel, 13-16% chromium and 7% iron
- 2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazole
- Fumonisin B1
- 呋喃
- Glu-P-1 (2-Amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole)
- Glu-P-2 (2-Aminodipyrido[1,2-a:3',2'-d]imidazole)
- Glycidaldehyde
- 灰黄霉素
- HC Blue No. 1
- 七氯
- 六氯苯
- 六氯乙烷
- 六氯环己烷s
- 六甲基磷酰胺 (HMPA)
- 人类免疫缺陷病毒 type 2 (infection with)
- 人类乳突病毒es: some types other than 16, 18, 31 and 33
- 联氨
- 1-Hydroxyanthraquinone
- Indeno[1,2,3-cd]pyrene
- Iron-dextran complex
- 异戊二烯
- 紫花果芸香碱
- 铅
- 磁场s (极低频)
- MeA-a-C (2-Amino-3-methyl-9H-pyrido[2,3-b]indole)
- Medroxyprogesterone acetate
- MeIQ (2-Amino-3,4-dimethylimidazo[4,5-f]quinoline)
- MeIQx (2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline)
- Merphalan
- 丙烯亚胺 (Propyleneimine)
- Methylazoxymethanol acetate
- 5-Methylchrysene
- 4,4'-Methylene bis(2-methylaniline)
- 4,4'-Methylenedianiline
- Methylmercury compounds
- 2-Methyl-1-nitroanthraquinone (uncertain purity)
- N-Methyl-N-nitrosourethane
- Methylthiouracil
- 甲硝唑
- Michler's base (4,4'-methylene-bis(N,N-dimethyl)benzenamine)
- 米氏酮 (4,4'-bis(dimethylamino)benzophenone)
- Microcystin-LR
- 灭蚁乐
- 丝裂霉素C
- 米托蒽醌
- 野百合碱
- 5-(Morpholinomethyl)-3-[(5-nitrofurfurylidene)amino]-2-oxazolidinone
- 萘酚平
- 萘
- 镍, metallic and alloys
- Niridazole
- 氨三乙酸 and its salts
- 5-Nitroacenaphthene
- 2-Nitroanisole
- 硝基苯
- 6-Nitrochrysene
- 护谷 (technical-grade)
- 2-Nitrofluorene
- 1-[(5-Nitrofurfurylidene)amino]-2-imidazolidinone
- N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide
- Nitrogen mustard N-oxide
- 硝基甲烷
- 2-硝基丙烷
- 1-硝基芘
- 4-Nitropyrene
- N-Nitrosodi-n-butylamine
- N-Nitrosodiethanolamine
- N-Nitrosodi-n-propylamine
- 3-(N-Nitrosomethylamino)propionitrile
- N-Nitrosomethylethylamine
- N-Nitrosomethylvinylamine
- N-Nitrosomorpholine
- N-亚硝基哌啶
- N-Nitrosopyrrolidine
- N-Nitrososarcosine
- Ochratoxin A
- Oestrogen-progestogen therapy, postmenopausal
- Oil Orange SS
- 奥沙西泮
- 坡缕石 (attapulgite) (long fibres, >5微米)
- Panfuran S (containing dihydroxymethylfuratrizine)
- 非那吡啶
- 苯巴比妥
- 酚酞
- Phenoxybenzamine hydrochloride
- Phenyl glycidyl ether
- 苯妥英
- PhIP (2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine)
- Polychlorophenols and their sodium salts (mixed exposures)
- Ponceau MX
- Ponceau 3R
- 溴酸钾
- Progestins
- Progestogen-only contraceptives
- 1,3-丙磺酸内酯
- Β-丙内酯
- 环氧丙烷
- 丙硫氧嘧啶(Propylthiouracil、PTU),抗甲状腺药物[12]
- 无线电波, such as, but not limited to, those associated with 移动电话 [13]
- 耐火陶瓷纤维
- 瑞德灵
- 黄樟素Safrole
- 日本血吸虫 (infection with)
- Sodium orthophenyl phenol
- Special-purpose fibres such as E-glass and '475' glass fibres
- Sterigmatocystin
- 链脲佐菌素
- 苯乙烯
- Sulfallate
- 四氟乙烯
- 四硝基甲烷
- 硫乙酰胺
- 4,4'-Thiodianiline
- Thiouracil
- 二氧化钛
- 二异氰酸甲苯(2,4-Toluene diiso-cyanate, 2,4-TDI)[14][15][16]
- 三氯氮芥 (Trimustine hydrochloride)
- Trp-P-1 (3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole)
- Trp-P-2 (3-Amino-1-methyl-5H-pyrido[4,3-b]indole)
- 台盼蓝
- 乌拉莫司汀
- 五氧化二钒
- 乙酸乙烯酯
- 4-乙烯基环己烯
- 4-Vinylcyclohexene diepoxide
- 扎西他滨
- 齐多夫定(Zidovudine,AZT)
- 阿斯巴甜[17]
混合物
[编辑]接触场合
[编辑]注释
[编辑]- 脚注
- ^1 Evaluated as a group.
- ^2 There is limited evidence in humans that coffee drinking is carcinogenic in the urinary bladder.
- ^3 There is some evidence of an inverse relationship between coffee drinking and cancer of the large bowel.
引用
[编辑]- ^ Agents Classified by the IARC Monographs, Volumes 1–135. [2024-05-10]. (原始内容存档于2024-05-02).
- ^ 谈环境中的致癌物 (页面存档备份,存于互联网档案馆) - 台北荣民总医院 毒物科 杨振昌医师
- ^ preamble to the IARC Monographs (页面存档备份,存于互联网档案馆)pdf
- ^ 存档副本. [2014-11-24]. (原始内容存档于2020-02-03).
- ^ 指定「危險物與有害物標示及通識規則 「危險物與有害物標示及通識規則」第二條第二款 」第二條第二款公告適用之 1,089 種危害物質名單 (PDF). [2014-11-24]. (原始内容存档 (PDF)于2014-11-29).
- ^ [1][永久失效链接]
- ^ Bracken Fern - Bracken Fern or Brake Fern (Pteridium aquilinum) - Plants toxic to animals (页面存档备份,存于互联网档案馆) - Veterinary Medicine library at U of Illinois
- ^ 存档副本. [2014-11-24]. (原始内容存档于2019-07-28).
- ^ 存档副本 (PDF). [2014-11-24]. (原始内容存档 (PDF)于2016-03-03).
- ^ 存档副本. [2014-09-20]. (原始内容存档于2020-02-03).
- ^ 物质安全资料表 (页面存档备份,存于互联网档案馆) - 劳动部劳动及职业安全卫生研究所
- ^ 存档副本. [2014-11-24]. (原始内容存档于2014-11-18).
- ^ Press release No 208, 31 May 2011 (页面存档备份,存于互联网档案馆), IARC classifies Radiofrequency Electromagnetic Fields as possibly carcinogenic to humans
- ^ 二异氰酸甲苯 (页面存档备份,存于互联网档案馆) - 行政院毒灾防救管理资讯系统
- ^ 2,4-二异氰酸甲苯健康危害 (页面存档备份,存于互联网档案馆) - 国立阳明大学环境卫生研究所
- ^ 中华民国七十六年一月十五日,台北县某工厂因二异氰酸甲苯(Toluene diisocyanate , TDI) (页面存档备份,存于互联网档案馆) - 卫生福利部疾病管制署
- ^ 世卫组织:阿斯巴甜可能致癌. 联合国新闻. 2023-07-13 [2023-07-14] (中文).
- ^ J, Wilbourn; C, Partensky; WG., Morgan. Printing Processes and Printing Inks, Carbon Black and Some Nitro Compounds. International Agency for Research on Cancer. 1996 [2023-10-31]. PMID 9148039. (原始内容存档于2022-12-22).
- ^ Printing Processes and Printing Inks, Carbon Black and Some Nitro Compounds. IARC Publications Website. [2023-10-31]. (原始内容存档于2023-10-31).
外部链接
[编辑]
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