安非他尼
外观
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临床资料 | |
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ATC码 |
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法律规范状态 | |
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识别信息 | |
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CAS号 | 17590-01-1 ![]() |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.037.767 |
化学信息 | |
化学式 | C17H18N2 |
摩尔质量 | 250.338 |
3D模型(JSmol) | |
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安非他尼(英语:Amfetaminil或amphetaminil)也叫苯丙苄腈胺[1]或AN-1,商品名Aponeuron,是一种从苯丙胺中提取的兴奋剂药物,开发于1970年代,用于治疗肥胖症、[2]注意力不足过动症[3][4]和发作性嗜睡病。[5]由于存在滥用问题,它在很大程度上已退出临床使用。[6]该药物是苯丙胺的前体药物[7][8]
立体化学
[编辑]安非他尼是一种具有两个立体异构中心的分子。因此,存在四种不同的立体异构体:
- (R)-2-[(R)-1-苯基丙-2-基氨基]-2-苯基乙腈,CAS号:478392-08-4
- (S)-2-[(S)-1-苯基丙-2-基氨基]-2-苯基乙腈,CAS号:478392-12-0
- (R)-2-[(S)-1-苯基丙-2-基氨基]-2-苯基乙腈,CAS号:478392-10-4
- (S)-2-[(R)-1-苯基丙-2-基氨基]-2-苯基乙腈,CAS号:478392-14-2
参考资料
[编辑]- ^ Morton IK, Hall JM. Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. 6 December 2012: 13–. ISBN 978-94-011-4439-1.
- ^ Harris LS. The stimulants and hallucinogens under consideration: a brief overview of their chemistry and pharmacology. Drug and Alcohol Dependence. June 1986, 17 (2–3): 107–18. PMID 2874966. doi:10.1016/0376-8716(86)90002-5.
- ^ Meyer-Probst B, Vehreschild T. [Influencing the lack of concentration in hyperkinetic school children with Aponeuron]. Psychiatrie, Neurologie, und Medizinische Psychologie. August 1976, 28 (8): 491–9. PMID 1005547 (德语).
- ^ Paclt I, Florian J, Brunclíková J, Růzicková I. [Effect of Aponeuron in the treatment of children with hyperkinetic syndrome]. Ceska a Slovenska Psychiatrie. May 1996,. 92 Suppl 1: 41–57. PMID 8768943 (捷克语).
- ^ Schlesser JL. Drugs Available Abroad - A Guide to Therapeutic Drugs Approved Outside the US.. Detroit: MEDEX Books. 1991.
- ^ Winter E. [Drug abuse and dependence of the amphetamine type with special regard to Amphetaminil (Aponeuron(R))]. Psychiatrie, Neurologie, und Medizinische Psychologie. September 1976, 28 (9): 513–25. PMID 1005549 (德语).
- ^ Dasgupta A. Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring: A Comprehensive Guide. John Wiley & Sons. 2 July 2012: 96–. ISBN 978-1-118-34785-0.
- ^ AHC Media, LLC. Pediatric Trauma Care II: A clinical reference for physicians and nurses caring for the acutely injured child. AHC Media, LLC. 17 March 2014: 118–. ISBN 978-1-934863-59-6.
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