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3-哌啶甲酸

維基百科,自由的百科全書
3-哌啶甲酸
識別資訊
  • piperidine-3-carboxylic acid
CAS號498-95-3
PubChem CID
IUPHAR/BPS
ChemSpider
ChEMBL
CompTox Dashboard英語CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.007.159 編輯維基數據鏈接
化學資訊
化學式C6H11NO2
摩爾質量129.16 g·mol−1
3D模型(JSmol英語JSmol
  • C1CC(CNC1)C(=O)O

3-哌啶甲酸是一種有機化合物,化學式為C6H11NO2,它是可溶於水的白色晶體。[1]

合成與性質

[編輯]

3-哌啶甲酸可由煙酸的氫化反應製得。

它和乙醇在酸的催化下進行酯化反應,得到3-哌啶甲酸乙酯。[2]

3-哌啶甲酸是一種Γ-氨基丁酸(GABA)再攝取抑制劑[3],常用於相關研究[4][5]

參考文獻

[編輯]
  1. ^ 3-哌啶甲酸頁面存檔備份,存於網際網路檔案館). ChemicalBook. [2019-3-22]
  2. ^ 李運波,唐鳳翔,孟春 等. 3-哌啶甲酸及其衍生物的合成與應用研究進展(PDF頁面存檔備份,存於網際網路檔案館)). 有機化學, 2009, 29(7).
  3. ^ Macdonald, R.L. Eadie, Mervyn J.; Vajda, Frank J. E. , 編. Antiepileptic drugs: pharmacology and therapeutics First. [S.l.]: Springer. 2012: 130. ISBN 978-3-642-64244-9. In contrast, prolonged (1 h) exposure to gabapentin enhanced the shunting effect on CAl region excitatory postsynaptic potentials induced by the GABA uptake inhibitor, nipecotic acid, which promotes GABA release. 
  4. ^ Takahashi K, Miyoshi S, Kaneko A, Copenhagen DR. Actions of nipecotic acid and SKF89976A on GABA transporter in cone-driven horizontal cells dissociated from the catfish retina. Jpn. J. Physiol. 1995, 45 (3): 457–73 [2019-03-22]. PMID 7474528. doi:10.2170/jjphysiol.45.457. (原始內容存檔於2020-02-02). 
  5. ^ Wahab A, Heinemann U, Albus K. Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures. Epilepsy Research. October 2009, 86 (2-3): 113–23 [2019-03-22]. PMID 19535226. doi:10.1016/j.eplepsyres.2009.05.008. (原始內容存檔於2020-02-02).