周期蛋白D1
外觀
G1/S-特異性周期蛋白-D1是一個由人類CCND1基因所編碼的蛋白質[1][2]。
該基因編碼的蛋白質屬於高度保守的周期蛋白家族,該家族成員的顯著特徵是貫穿細胞周期,其蛋白質豐度周期性地急劇改變。周期蛋白作為CDK(周期蛋白依賴性激酶)的調節因子。不同的周期蛋白表現出各自獨特的表達及降解特性,這有助於每個有絲分裂事件在時間上的協調性。周期蛋白D1這種亞型的周期蛋白與CDK4或CDK6形成複合物並作為它們的調節亞基,這兩種周期蛋白依賴性激酶對於G1到S期的轉變來說是不可或缺的。該蛋白表現出與抑癌基因Rb有着相互作用,且此基因的表達受Rb的正向調控。周期蛋白D1發生突變、擴增及過表達將會改變細胞周期進程,這些現象常發生在多種腫瘤中並可能導致腫瘤發生[3]。
![](http://upload.wikimedia.org/wikipedia/commons/thumb/a/af/Mantle_cell_lymphoma_-_intermed_mag_-_cyclin_D1.jpg/125px-Mantle_cell_lymphoma_-_intermed_mag_-_cyclin_D1.jpg)
使用周期蛋白D1進行免疫組化染色可用於診斷套細胞淋巴瘤。
另見
[編輯]參考文獻
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- ^ Entrez Gene: CCND1 cyclin D1. (原始內容存檔於2009-05-11).
深入閱讀
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