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氧丙咪嗪

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氧丙咪嗪
Skeletal formula of imipraminoxide
Ball-and-stick model of the imipraminoxide molecule
臨床資料
商品名英語Drug nomenclatureImiprex, Elepsin
給藥途徑Oral
ATC碼
法律規範狀態
法律規範
  • 處方藥(-only)
藥物動力學數據
生物半衰期Intravenous: 1.8 hours[1]
識別資訊
  • 3-(5,6-dihydrobenzo[b][f]benzazepin- 11-yl)- N,N-dimethyl- propan- 1-amine N-oxide
CAS號6829-98-7
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard英語CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.027.188 編輯維基數據鏈接
化學資訊
化學式C19H24N2O
摩爾質量296.41 g·mol−1

氧丙咪嗪(英語:Imipraminoxide 或 imipramine N-oxide,商品名:ImiprexElepsin),分子式C19H24N2O,是一種用於治療重性抑鬱疾患三環類抗抑鬱藥(TCA),1960年代開始在歐洲使用,也是丙咪嗪在體內的代謝產物[3][4][5][6]

參考文獻

[編輯]
  1. ^ Florencio Zaragoza Dörwald. Lead Optimization for Medicinal Chemists: Pharmacokinetic Properties of Functional Groups and Organic Compounds. John Wiley & Sons. 4 February 2013: 311–. ISBN 978-3-527-64565-7. 
  2. ^ Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control]. Diário Oficial da União. 2023-03-31 (2023-04-04) [2023-08-16]. (原始內容存檔於2023-08-03) (巴西葡萄牙語). 
  3. ^ Swiss Pharmaceutical Society. Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. 2000: 546. ISBN 3-88763-075-0. 
  4. ^ Dictionary of organic compounds. London: Chapman & Hall. 1996: 3877. ISBN 0-412-54090-8. 
  5. ^ FAURBYE A, JACOBSEN O, KRISTJANSEN P, MUNKVAD I. Imipramine-N-oxide: preliminary investigation of a new antidepressive drug. The American Journal of Psychiatry. September 1963, 120 (3): 277–8 [2023-11-21]. PMID 13944543. doi:10.1176/ajp.120.3.277. (原始內容存檔於2019-12-10). 
  6. ^ Lingjaerde O. [Imiprex "Dumex" (imipramine oxide). A new tricyclic antidepressive agent]. Tidsskrift for den Norske Lægeforening. November 1971, 91 (31): 2267–8. PMID 5133241 (挪威語). 

外部連結

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