昂丹司琼
外观
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临床资料 | |
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商品名 | Zofran, Ondisolv, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a601209 |
怀孕分级 |
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给药途径 | by mouth, rectal, IV, IM |
ATC码 | |
法律规范状态 | |
法律规范 |
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药物动力学数据 | |
生物利用度 | ~60% |
血浆蛋白结合率 | 70%-76% |
药物代谢 | Liver (CYP3A4, CYP1A2, CYP2D6) |
生物半衰期 | 5.7 hours |
排泄途径 | Kidney |
识别信息 | |
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CAS号 | 99614-02-5 ![]() |
PubChem CID | |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.110.918 |
化学信息 | |
化学式 | C18H19N3O |
摩尔质量 | 293.4 g/mol |
3D模型(JSmol) | |
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昂丹司琼(Ondansetron),常见商品名 Zofran,是一种用于减少手术、化疗、放射治疗后,恶心呕吐的药物[1]。亦可用于治疗肠胃炎[2][3]。但对于动晕症几乎无治疗效果[4]。本品可经口服给药,也可以肌肉注射或静脉注射使用[1]。
常见的副作用包括腹泻、头痛、嗜睡和皮肤搔痒[1]。严重的话可能诱发QT波延长或是全身性过敏反应[1]。妊娠期间用药似为安全,但相关证据仍不足够[1]。此药物是一种高专一性的血清素5-HT3受体拮抗剂[1],并不会针对多巴胺受体或蕈碱类受器[5]。
昂丹司琼在1990年首次被作为药物使用[6]。本品列名于世界卫生组织基本药物标准清单,该清单纪录了一般卫生体系最需要的药物[7]。目前已是学名药[1]。其于发展中国家的每剂注射剂型批发价约介于0.1到0.76美金[8]。在美国,每颗药物大约花费1.37美金[1]。
参考文献
[编辑]- ^ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Ondansetron Hydrochloride. The American Society of Health-System Pharmacists. [February 11, 2017]. (原始内容存档于2016-05-03).
- ^ Schnadower, D; Finkelstein, Y; Freedman, SB. Ondansetron and probiotics in the management of pediatric acute gastroenteritis in developed countries.. Current Opinion in Gastroenterology. January 2015, 31 (1): 1–6. PMID 25333367. doi:10.1097/mog.0000000000000132.
- ^ Freedman, SB; Ali, S; Oleszczuk, M; Gouin, S; Hartling, L. Treatment of acute gastroenteritis in children: an overview of systematic reviews of interventions commonly used in developed countries.. Evidence-based child health : a Cochrane review journal. July 2013, 8 (4): 1123–37. PMID 23877938. doi:10.1002/ebch.1932.
- ^ Sutton, M; Mounsey, AL; Russell, RG. FPIN's Clinical Inquiries. Treatment of motion sickness.. American Family Physician. 15 July 2012, 86 (2): 192–5. PMID 22962932.
- ^ Miloro, ed. by Michael. Peterson's principles of oral and maxillofacial surgery. 3rd. Shelton, CT: People's Medical Pub. House-USA. 2012: 86 [2018-02-03]. ISBN 978-1-60795-111-7. (原始内容存档于2016-02-01).
- ^ Sneader, Walter. Drug discovery: a history Rev. and updated. Chichester: Wiley. 2005: 217 [2018-02-03]. ISBN 978-0-471-89979-2. (原始内容存档于2016-02-01).
- ^ WHO Model List of Essential Medicines (19th List) (PDF). World Health Organization. April 2015 [8 December 2016]. (原始内容存档 (PDF)于2016-12-13).
- ^ Ondansetron. International Drug Price Indicator Guide. [26 January 2016]. (原始内容存档于2017-05-10).
外部链接
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